The trifluoroacetic acid solvent system. Part VI. Density measurements

Trifluoroacetic Acid as a Peptide Solvent*

A method employing reverse phase high performance liquid chromatography has been developed for the purification of large denatured peptides. The cyanogen bromide fragments of hemoglobin a, 8, and y chains (13 to 91 residues in length) could be separated and recovered in 71 to 95% yields using LiChrosorb C-8 columns and a binary solvent system consisting of 0.013 M trifluoroacetic acid in water ...

MRI of trifluoroacetic acid encapsulated into liposomes

within ~9min. The slice thickness is 10mm and the resolution is 0.125cm/pix. The resulting SNR is about 7.4. Fig. 2: Determination of the detection limit. The SNR is plotted for different concentrations of the liposomes. The red line shows the theoretical SNR normalised to the highest concentration. Fig. 1: Spectra of the liposomes after washing (bottom) and the corresponding supernatant of the...

Trifluoroacetic acid as excipient destabilizes melittin causing the selective aggregation of melittin within the centrin-melittin-trifluoroacetic acid complexa)

Trifluoroacetic acid (TFA) may be the cause of the bottleneck in high resolution structure determination for protein-peptide complexes. Fragment based drug design often involves the use of synthetic peptides which contain TFA (excipient). Our goal was to explore the effects of this excipient on a model complex: centrin-melittin-TFA. We performed Fourier transform infrared, two-dimensional infra...

Hæmatological Technique. Part VI

Part VI Example Problems

An object is cloaked if its presence cannot be detected by an observer using electromagnetic or other forms of imaging. In fact, the observer should not notice that cloaking is even occurring. Cloaking has a long history in science fiction, but recent developments have put the idea on a firmer mathematical and physical basis. Suppose that an observer seeks to image some bounded region Ω in spac...